Anhydrous hydrogen fluoride is easy to prepare and has a large yield. It is an important raw material for the production of fluoride salts, fluororubber, fluororefrigerants, fluoroplastics, and fluoropharmaceuticals. It is also used in electroplating, reagents, fermentation, ceramic treatment, and the manufacture of fluorine-containing resins and flame retardants.

Anhydrous hydrogen fluoride has high activity and can bind, displace, or react with any negative element or group other than fluorine. It has strong proton donating ability and good catalytic activity. It serves as an active catalyst in alkylation, isomerization, and polymerization reactions in organic chemistry.

Anhydrous hydrogen fluoride, used as a strong acidic corrosive agent in the electronics industry, can be used in combination with nitric acid, acetic acid, ammonia water, and hydrogen peroxide.